Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 11 Reviews
8.6
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Proprietary BlendBoswellia (Indian Frankincense) (gum) extract, Bromelain (600 GDU/g), Ginger (root) extract, White Willow (bark) (Salix alba) extract, Cayenne (fruit) powder
800 mg
**
Hyaluronic Acid (as Sodium Hyaluronate)
100 mg
**
Top Medical Research Studies
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
Most Useful Reviews
10
Improved skin hydration
4 people found this helpful
An excellent supplement for skin and joints. I noticed remarkable improvement in just two weeks; my skin became more hydrated and my expression lines fuller. I am free of knee and shoulder pain.
Read More
9
Joint pain reduced
4 people found this helpful
I purchased this for my husband, who had been complaining of joint pain during physical activity. After less than six months, he reported that his joints hardly hurt any longer, and he requests more of this product, which he takes alongside glucosamine and chondroitin.
Read More
9
Pain relief achieved
2 people found this helpful
I highly recommend this for those with joint issues. It has been a great help for my injuries, relieving the pain effectively. Additionally, my skin condition improved due to previous thyroid-related dryness. The medium capsules are suitable for vegetarians.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
- All Researches
9
Hyaluronic acid aids pelvic pain relief
We explored the effects of high molecular weight hyaluronic acid (HMWHA) on pelvic pain in pregnant women through a pilot study.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
In our research, 200 women received daily oral supplements of HMWHA along with other nutrients. In comparison, 50 women formed a control group taking magnesium only.
Results showed significant reductions in pelvic pain, preterm birth, contractions, and hospitalizations in the treatment group. Our findings suggest that HMWHA could be a promising option for managing pelvic pain during pregnancy.
Read More
9
We explored the impact of high molecular weight sodium hyaluronate (HMW-HA) on pelvic pain caused by radiation-induced cystitis. In this prospective study involving 30 patients across seven centers in France, participants received six weekly intravesical instillations of HMW-HA.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Results showed a notable reduction in pelvic pain intensity and improvements in other symptoms, like hematuria and urinary frequency. These positive outcomes were stable even four weeks after treatment. Thankfully, the therapy was well-tolerated with minimal side effects.
However, we recognize that more in-depth studies are needed to solidify these findings.
Read More
9
Positive effects on postoperative recovery
We evaluated how New Cross linked Hyaluronan Gel (NCH gel) influences patients' quality of life after surgery for Deep Infiltrating Endometriosis (DIE). In a well-structured randomized controlled trial, patients received either the gel or a placebo saline solution post-surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Our findings showed that those treated with NCH gel reported significantly lower pain levels and improved overall health scores at three and six months after surgery. This suggests that using NCH gel can enhance recovery and quality of life following endometriosis surgery.
Read More
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Read More
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Improved skin hydration
4 people found this helpful
An excellent supplement for skin and joints. I noticed remarkable improvement in just two weeks; my skin became more hydrated and my expression lines fuller. I am free of knee and shoulder pain.
Read More
9
Joint pain reduced
4 people found this helpful
I purchased this for my husband, who had been complaining of joint pain during physical activity. After less than six months, he reported that his joints hardly hurt any longer, and he requests more of this product, which he takes alongside glucosamine and chondroitin.
Read More
9
Pain relief achieved
2 people found this helpful
I highly recommend this for those with joint issues. It has been a great help for my injuries, relieving the pain effectively. Additionally, my skin condition improved due to previous thyroid-related dryness. The medium capsules are suitable for vegetarians.
Read More
9
Relieved vaccine pain
1 people found this helpful
This has considerably improved my joint pain, which stemmed from the Pfizer COVID vaccine. It has been the only supplement that has truly helped me.
Read More
9
Disappeared arthritis pain
5 people found this helpful
I really liked this supplement! Having a history of arthritis, thanks to Boswellia, the pains melted away and it became easier to walk. Additionally, my skin has been hydrated.
Read More
Frequently Asked Questions
9
Effective product noted
1 people found this helpful
This product is remarkably effective; I observed a difference in my joint pain within a week of usage! I'm very surprised and satisfied with the results.
10
Improved skin hydration
4 people found this helpful
An excellent supplement for skin and joints. I noticed remarkable improvement in just two weeks; my skin became more hydrated and my expression lines fuller. I am free of knee and shoulder pain.
9
Joint pain reduced
4 people found this helpful
I purchased this for my husband, who had been complaining of joint pain during physical activity. After less than six months, he reported that his joints hardly hurt any longer, and he requests more of this product, which he takes alongside glucosamine and chondroitin.
9
Relieved vaccine pain
1 people found this helpful
This has considerably improved my joint pain, which stemmed from the Pfizer COVID vaccine. It has been the only supplement that has truly helped me.
9
Disappeared arthritis pain
5 people found this helpful
I really liked this supplement! Having a history of arthritis, thanks to Boswellia, the pains melted away and it became easier to walk. Additionally, my skin has been hydrated.
7.5
Alleviated arthritic pain
YouTheory produces excellent products, including this hyaluronic acid, which has significantly helped with the arthritic pain in my hip.
7.5
Pain and skin improvement
I ordered hyaluronic acid based on positive reviews. This advanced formula, which I combine with collagen, aids in alleviating my pelvic pain and enhances my skin's appearance.
7.5
Reduced joint pain
2 people found this helpful
The quality is outstanding; this hyaluronic acid purifies the skin and diminishes wrinkles. I noticed a significant reduction in the lines under my eyes, and it has alleviated my joint pain remarkably. Using it with collagen yields nice results.
9
We evaluated the use of hyaluronic acid and chondroitin sulfate through intravesical instillation to treat refractory painful bladder syndrome in forty patients.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
Over several months, patients received weekly treatments and reported significant reductions in pain and symptom severity, as measured by multiple scales.
Impressively, all participants tolerated the treatment well with no documented side effects. Overall, our findings suggest that this approach is both safe and effective for managing pelvic pain.
We analyzed the effects of Hyaluronic Acid-Chondroitin Sulfate (HA-CS) on women experiencing pelvic pain and urinary urgency due to interstitial cystitis/painful bladder syndrome (IC/PBS). Seventeen patients received this treatment while waiting for surgical intervention for urinary issues.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
After treatment, we observed notable reductions in pain and the frequency of urgent bathroom visits. Impressively, 82.3% of patients reported significant relief, indicating HA-CS may aid in identifying those with pure stress urinary incontinence.
8
We investigated whether high-molecular-weight hyaluronic acid (HMWHA), along with other supplements, helps reduce pelvic pain and improve hematoma resorption in pregnant women facing threatened miscarriage.
In our study, we enrolled 56 women experiencing this condition and divided them into two groups: one received standard care, while the other combined standard care with HMWHA and additional nutrients.
Results showed that the treatment group not only experienced quicker resorption of the hematoma but also reported a faster relief from symptoms like abdominal pain and bleeding.
In our study, we enrolled 56 women experiencing this condition and divided them into two groups: one received standard care, while the other combined standard care with HMWHA and additional nutrients.
Results showed that the treatment group not only experienced quicker resorption of the hematoma but also reported a faster relief from symptoms like abdominal pain and bleeding.
This study looked into how well hyaluronic acid (HA) treatments help relieve pelvic pain in patients with bladder pain syndrome and urinary tract infections. We found that, after long-term use, patients experienced significant reductions in symptoms like urinary bladder pain and urgency. Remarkably, around 75% of participants saw complete relief and needed no further treatments.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
Overall, our results suggest that HA can be a valuable option for improving quality of life in those suffering from these conditions, making a positive impact with few side effects.
8
We aimed to understand how effective intravesical hyaluronic acid (HA) treatment is for women suffering from refractory interstitial cystitis/painful bladder syndrome (IC/PBS). In our study, 33 patients with significant pain received weekly HA instillations for four weeks. We assessed their pain levels and overall symptoms at the end of the treatment.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
The results indicated that HA instillation was both effective and safe, helping to reduce pain among participants. Interestingly, we found that previous treatments or the presence of Hunner's ulcer did not influence HA's effectiveness.
9
We investigated the effects of an intravesical treatment combining sodium hyaluronate and chondroitin sulfate on women suffering from interstitial cystitis/bladder pain syndrome. Over several months, participants reported significant improvements in their pelvic pain and symptoms, indicated by notable drops in their questionnaire scores.
We observed that this treatment was not only effective but also safe, with no side effects reported. However, we recognize the need for larger, more extensive studies to further validate these promising outcomes.
We observed that this treatment was not only effective but also safe, with no side effects reported. However, we recognize the need for larger, more extensive studies to further validate these promising outcomes.
References
- Gubbiotti M, Rubilotta E, Bacchiani M, Cocci A, Rosadi S, et al. Intravesical administration of highly concentrated hyaluronic acid and chondroitin sulfate as add-on therapy for chemical cystitis induced by Bacillus Calmette-Guérin (BCG) immunotherapy. Int Urol Nephrol. 2025. doi:10.1007/s11255-025-04375-8
- Falabella R, Morra S, Milella L, LA Falce S, DI Fino G, et al. Overactive bladder: results from patients treated by hyaluronic acid-chondroitin sulphate therapy. Minerva Urol Nephrol. 2024. doi:10.23736/S2724-6051.24.05786-0
- Porcaro G, Laganà AS, Neri I, Aragona C. The Association of High-Molecular-Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6, and Vitamin D Improves Subchorionic Hematoma Resorption in Women with Threatened Miscarriage: A Pilot Clinical Study. J Clin Med. 2024;13. doi:10.3390/jcm13030706
- Parente E, Colannino G, Bilotta G, Espinola MSB, Proietti S, et al. Effect of Oral High Molecular Weight Hyaluronic Acid (HMWHA), Alpha Lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D Supplementation in Pregnant Women: A Retrospective Observational Pilot Study. Clin Pract. 2023;13:1123. doi:10.3390/clinpract13050100
- Ghaith AF, Radwan MH, Rashed Taha M, Elbendary MA, Al Damhogy ME, et al. Evaluation of pain and quality of life after hyaluronic acid instillation in addition to botulinum toxin-A injection in women with refractory Interstitial Cystitis/Painful Bladder Syndrome: A pilot study. Arch Ital Urol Androl. 2022;94:447. doi:10.4081/aiua.2022.4.447
- Baboudjian M, Fourmarier M, Clement C, Cherasse A, Graziana JP, et al. Intravesical instillation of high molecular weight sodium hyaluronate in radiation-induced cystitis: a prospective pilot study. World J Urol. 2022;40:141. doi:10.1007/s00345-021-03837-9
- Argüelles Rojas S, Oviedo Ortega JG, Velasco Sordo R. Interstitial Cystitis: Diagnosis and Treatment in a Pregnant Patient. Cureus. 2021;13:e14549. doi:10.7759/cureus.14549
- Cai T, Gallelli L, Cione E, Verze P, Palmieri A, et al. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva Urol Nephrol. 2022;74:780. doi:10.23736/S2724-6051.21.04141-2
- Peng YC, Yueh-Hsia Chiu S, Feng M, Liang CC. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwan J Obstet Gynecol. 2020;59:922. doi:10.1016/j.tjog.2020.09.021
- Ekin M, Kaya C, Erdoğan ŞV, Bahçeci E, Baghaki S, et al. The effect of new cross linked hyaluronan gel on quality of life of patients after deep infiltrating endometriosis surgery: a randomized controlled pilot study. J Obstet Gynaecol. 2021;41:263. doi:10.1080/01443615.2020.1755628
- Scarneciu I, Bungau S, Lupu AM, Scarneciu CC, Bratu OG, et al. Efficacy of instillation treatment with hyaluronic acid in relieving symptoms in patients with BPS/IC and uncomplicated recurrent urinary tract infections - Long-term results of a multicenter study. Eur J Pharm Sci. 2019;139:105067. doi:10.1016/j.ejps.2019.105067
- Sherif H, Sebay A, Kandeel W, Othman T, Fathi A, et al. Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome. Turk J Urol. 2019;45:296. doi:10.5152/tud.2018.63600
- Morelli M, Mocciaro R, Venturella R, Albano A, Sacchinelli A, et al. Hyaluronic acid-chondroitin sulfate: a potential factor to select pure stress urinary incontinence in patients with interstitial cystitis⁄painful bladder syndrome and mixed incontinence symptoms. Minerva Ginecol. 2015;67:121.
- Huang W, Wang F, Wu C, Hu W. Efficacy and safety of pirarubicin combined with hyaluronic acid for non-muscle invasive bladder cancer after transurethral resection: a prospective, randomized study. Int Urol Nephrol. 2015;47:631. doi:10.1007/s11255-015-0940-1
- Kim A, Lim B, Song M, Choo MS. Pretreatment features to influence effectiveness of intravesical hyaluronic Acid instillation in refractory interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2014;18:163. doi:10.5213/inj.2014.18.3.163
- Giberti C, Gallo F, Cortese P, Schenone M. Combined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol. 2013;5:175. doi:10.1177/1756287213490052
